Skeletal Biotech Lab Home Page

Hebrew University

Last Updated:
15-Jan-2012

Pelled Gadi, PhD; DMD
(Scientist)


Email: gadip@ekmd.huji.ac.il

Subjects of interest

  • Ex vivo and in vivo skeletal tissue engineering.
  • Bioreactors and microgravity.
  • Osteoarthritis.
  • Non-viral gene delivery.

Publications list: (recent five years)

Kimelman-Bleich N, Kallai I, Lieberman JR, Schwarz EM, Pelled G, Gazit D.
Gene therapy approaches to regenerating bone.
Adv Drug Deliv Rev. (2012)  [Online - Ahead of Print]


Sheyn D, Kallai I, Tawackoli W, Cohn Yakubovich D, Oh A, Su S, Da X, Lavi A, Kimelman-Bleich N, Zilberman Y, Li N, Bae H, Gazit Z, Pelled G, Gazit D.
Gene-modified adult stem cells regenerate vertebral bone defect in a rat model.
Mol Pharm, 8(5):1592-601. (2011) 
[Full text article]

Kimelman-Bleich N, Seliktar D, Kallai I, Helm GA, Gazit Z, Gazit D, Pelled G.
The effect of ex vivo dynamic loading on the osteogenic differentiation of genetically engineered mesenchymal stem cell model.
J Tissue Eng Regen Med, 5(5):384-93. (2011) 
[Full text article]

Smith BJ, Sutton GM, Wu X, Yu G, Goh BC, Hebert T, Pelled G, Gazit Z, Gazit D, Butler AA, Gimble JM.
Ovariectomy and genes encoding core circadian regulatory proteins in murine bone.
Osteoporosis International, 
22(5):1633-39. [Full text article]

Kallai I, Mizrahi O, Tawackoli W, Gazit Z
, Pelled G, Gazit D.
Micro–Computed Tomography–Based Structural Analysis of Various Bone-Tissue Regeneration Models.
Nature Protocols, 
6(1):105-10. (2011) [Full text article]

Zhang Y, Gazit Z, Pelled G, Gazit D, Vunjak-Novakovic G.
Patterning osteogenesis by inducible gene expression in microfluidic culture systems.

Integrative Biology, 
3(1):39-47. (2011) [Full text article]

Kimelman-Bleich N, Pelled G, Zilberman Y, Kallai I, Mizrahi O, Tawackoli W, Gazit Z, Gazit D.

Targeted Gene-and-host Progenitor Cell Therapy for Nonunion Bone Fracture Repair.

Molecular Therapy, 
19(1):53-9. (2011) [Full text article]

Sheyn D, Pelled G, Netanely D, Domany E, Gazit D.
The Effect of Simulated Microgravity on Human Mesenchymal Stem Cells Cultured in an Osteogenic Differentiation System: A Bioinformatics Study.
Tissue Eng Part A, 16(11): 3403-3412. (2010) [Full text article]

Sheyn D, Rüthemann M, Mizrahi O, Kallai I, Zilberman Y, Tawackoli W, Kanim LE, Zhao L, Bae H, Pelled G, Snedeker J, Gazit D.
Genetically Modified Mesenchymal Stem Cells Induce Mechanically Stable Posterior Spine Fusion.
Tissue Eng
Part A, 16(12):3679-86. (2010) [Full text article]

Kallai I, van Lenthe GH, Ruffoni D, Zilberman Y, Müller R, Pelled G, Gazit D.
Quantitative, structural, and image-based mechanical analysis of nonunion fracture repaired by genetically engineered mesenchymal stem cells.

J Biomech 43(12):2315-20. (2010)
[Full text article]

Garty S, Kimelman-Bleich N, Hayouka Z, Cohn D, Friedler A, Pelled G, Gazit D.
Peptide-Modified "Smart" Hydrogels and Genetically Engineered Stem Cells for Skeletal Tissue Engineering.
Biomacromolecules 11(6):1516-1526. (2010)
[Full text article]


Sheyn D, Mizrahi O, Benjamin S, Pelled G, Gazit D.
Genetically modified cells in regenerative medicine and tissue engineering.
Advanced Drug Delivery Reviews
62(7-8):683-698. (2010) [Full text article]


Saar G, Zilberman Y, Shinar H, Keinan-Adamsky K, Pelled G, Gazit D, Navon G.
Monitoring of the Effect of Intervertebral Disc Nucleus Pulposus Ablation by MRI.
NMR in Biomedicine 23(6):554-62. (2010)
[Full text article]


Pelled G, Ben Arav A, Hock C, Reynolds DG, Yazici C, Zilberman Y, Gazit Z, Awad H, Gazit D, Schwarz E.

Direct Gene Therapy for Bone Regeneration: Gene Delivery, Animal Models and Outcome Measures.
Tissue Eng Part B 16(1):13-20. (2010) [Full text article]

Kimelman-Bleich N, Pelled G, Sheyn D, Kallai I, Zilberman Y, Mizrahi O, Tal Y, Tawackoli W, Gazit Z, Gazit D.
The use of a synthetic oxygen carrier-enriched hydrogel to enhance mesenchymal stem cell-based bone formation in vivo.
Biomaterials 30(27):4639-48. (2009) [Full text article]

Stok KS, Pelled G, Zilberman Y, Kallai I, Goldhahn J, Gazit D, Muller R.
Revealing the interplay of bone and cartilage in osteoarthritis through multimodel imaging of murine joints.
Bone 45(3):414-22. (2009)
[Full text article]


Snedeker JG, Ben-Arav A, Zilberman Y, Pelled G, Gazit D.
Functional Fibered Confocal Microscopy: a Promising Tool for Assessing Tendon Regeneration.
Tissue Eng Part C 15(3):485:491. (2009) [Full text article]


Dinser R, Pelled G, Muller-Ladner U, Gazit D, Neumann E.
Expression of Brachyury in mesenchymal progenitor cells leads to cartilage-like tissue that is resistant to the destructive effect of rheumatoid arthritis synovial fibroblasts.
J Tissue Eng Regen Med 3(2):124-8. (2009) [Full text article]


Snedeker JG, Pelled G, Zilberman Y, Ben Arav A, Huber E, Muller R, Gazit D.
An Analytical Model for Elucidating Tendon Tissue Structure and Biomechanical Function from in vivo Cellular Confocal Microscopy Images.
Cells Tissues Organs 190(2):111-119. (2009) [Full text article]


Gafni Y, Ptitsyn AA, Pelled G, Zilberman Y, Gimble JM, Gazit D.
Circadian Rhythm of Osteocalcin in the Maxillomandibular Complex.
J Dent Res 88(1):45-50. (2009) [Full text article]

Ziv R, Steinhardt Y, Pelled G, Gazit D, Rubinsky B.
Micro-electroporation of mesenchymal stem cells with alternating electrical current pulses. 
Biomed Microdevices 11(1):95-101. (2009) [Full text article]

Tai K, Pelled G, Sheyn D, Bershteyn A, Han L, Kallai I, Zilberman Y, Ortiz C, Gazit D.
Nanobiomechanics of Repair Bone Regenerated by Genetically Modified Mesenchymal Stem Cells.
Tissue Eng Part A 14(10):1709-20. (2008)
[Full text article]

Zilberman Y, Gafni Y, Pelled G, Gazit Z, Gazit D.
Bioluminescent imaging in bone.
Methods Mol Biol 455:261-72. (2008) [Full text article]

Wu X, Yu G, Parks H, Hebert T, Goh BC, Dietrich MA, Pelled G, Izadpanah R, Gazit D, Bunnell BA, Gimble JM.
Circadian mechanisms in murine and human bone marrow mesenchymal stem cells following dexamethasone exposure.
Bone 42(5):861-70. (2008)
 
[Full text article]

Sheyn D, Pelled G, Zilberman Y, Talasazan F, Frank JM, Gazit D, Gazit Z.
Nonvirally Engineered Porcine Adipose Tissue-Derived Stem Cells: Use in Posterior Spinal Fusion.
Stem Cells 26(4):1056-64. (2008) [Full text article]

Sheyn D, Kimelman-Bleich N, Pelled G, Zilberman Y, Gazit D, Gazit Z.
Ultrasound-based nonviral gene delivery induces bone formation in vivo.
Gene Ther 15(4):257-66. (2008) [Full text article]

Zilberman Y, Kallai I, Gafni Y, Pelled G, Kossodo S, Yared W, Gazit D.
Fluorescence molecular tomography enables in vivo visualization and quantification of nonunion fracture repair induced by genetically engineered mesenchymal stem cell.
J Orthop Res 26(4):522-30. (2008)
[Full text article]


Aslan H, Kimelman-Bleich N, Pelled G, Gazit D.
Molecular targets for tendon neoformation.
J Clin Invest 118(2):439-44. (2008)
[
Full text article]

 

Prof. Dan Gazit Dr. Zulma Gazit Dr.Gadi Pelled yoram Nadav kimelman Ilan Kallai

Olga

Shimon

Amir Yosi Navaro Lior Ben-Assaf
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