Skeletal Biotech Lab Home Page

Hebrew University
Last Updated:
19-Aug-2009

Prof. Gazit Dan, PhD; DMD
(Head, Skeletal Biotech Lab)

Prof. Dan Gazit
Email: dgaz@cc.huji.ac.il


Subjects of interest
  • Skeletal gene therapy & tissue engineering.
  • Stem cell isolation and characterization.
  • Novel gene discovery.
  • Nano technology in regenerative medicine.


(Last five years)

117. Sheyn D, Mizrahi O, Benjamin S, Pelled G, Gazit D. (2010) Genetically modified cells in regenerative medicine and tissue engineering. Advanced Drug Delivery Reviews, In Press.

116. Saar G, Zilberman Y, Shinar H, Keinan-Adamsky K, Pelled G, Gazit D, Navon G. (2010) Monitoring of the Effect of Intervertebral Disc Nucleus Pulposus Ablation by MRI. NMR in Biomedicine, In Press.

115. Pelled G, Ben Arav A, Hock C, Reynolds DG, Yazici C, Zilberman Y, Gazit Z, Awad H, Gazit D, Schwarz E. (2009) Direct Gene Therapy for Bone Regeneration: Gene Delivery, Animal Models and Outcome Measures. Tissue Eng Part A. In Press. [Online - Ahead of Print]

114. Kimelman-Bleich N, Pelled G, Sheyn D, Kallai I, Zilberman Y, Mizrahi O, Tal Y, Tawackoli W, Gazit Z, Gazit D. (2009) The use of a synthetic oxygen carrier-enriched hydrogel to enhance mesenchymal stem cell-based bone formation in vivo. Biomaterials 30(27):4639-48. [Full text article]

113.  Stok KS, Pelled G, Zilberman Y, Kallai I, Goldhahn J, Gazit D, Muller R. (2009) Revealing the interplay of bone and cartilage in osteoarthritis through multimodel imaging of murine joints. Bone 45(3):414-22. [Full text article]

112. Gazit D. (2009) Stem Cell Research: Regenerating the Skeleton and Craniofacial Complex. Alpha Omegan 102(1):31-4. [Full text article]

111. Snedeker JG, Ben-Arav A, Zilberman Y, Pelled G, Gazit D. (2009) Functional Fibered Confocal Microscopy: a Promising Tool for Assessing Tendon Regeneration. Tissue Eng Part C. [Online - Ahead of Print]

110. Dinser R, Pelled G, Muller-Ladner U, Gazit D, Neumann E. (2009) Expression of Brachyury in mesenchymal progenitor cells leads to cartilage-like tissue that is resistant to the destructive effect of rheumatoid arthritis synovial fibroblasts. J Tissue Eng Regen Med 3(2):124-8. [Full text article]

109. Czerninski R, Krichevsky S, Ashab Y, Gazit D, Patel V, Ben-Yehuda D. (2009) Promoter hypermethylation of mismatch repair genes, hMLH1 and hMSH2 in oral squamous cell carcinoma. Oral Diseases 15(3):206-13. [Full text article]

108. Snedeker JG, Pelled G, Zilberman Y, Ben Arav A, Huber E, Muller R, Gazit D. (2009) An Analytical Model for Elucidating Tendon Tissue Structure and Biomechanical Function from in vivo Cellular Confocal Microscopy Images. Cells Tissues Organs 190(2):111-119. [Full text article]

107. Aslan H, Sheyn D, Gazit D. (2009) Genetically engineered mesenchymal stem cells: application in spine therapy. Regen Med 4(1):99-108. [Full text article]

106. Gafni Y, Ptitsyn AA, Pelled G, Zilberman Y, Gimble JM, Gazit D. (2009) Circadian Rhythm of Osteocalcin in the Maxillomandibular Complex. J Dent Res 88(1):45-50. [Full text article]

105. Ziv R, Steinhardt Y, Pelled G, Gazit D, Rubinsky B. (2009) Micro-electroporation of mesenchymal stem cells with alternating electrical current pulses. Biomed Microdevices 11(1):95-101. [Full text article]

104. Steinhardt Y, Aslan H, Regev E, Zilberman Y, Kallai I, Gazit D, Gazit Z. (2008) Maxillofacial-Derived Stem Cells Regenerate Critical Mandibular Bone Defect. Tissue Eng Part A 14(11):1763-73. [Full text article] 

103. Tai K, Pelled G, Sheyn D, Bershteyn A, Han L, Kallai I, Zilberman Y, Ortiz C, Gazit D. (2008) Nanobiomechanics of Repair Bone Regenerated by Genetically Modified Mesenchymal Stem Cells. Tissue Eng Part A 14(10):1709-20. [Full text article]

102. Zilberman Y, Gafni Y, Pelled G, Gazit Z, Gazit D. (2008) Bioluminescent imaging in bone. Methods Mol Biol 455:261-72. [Full text article]

101. Wu X, Yu G, Parks H, Hebert T, Goh BC, Dietrich MA, Pelled G, Izadpanah R, Gazit D, Bunnell BA, Gimble JM. (2008) Circadian mechanisms in murine and human bone marrow mesenchymal stem cells following dexamethasone exposure. Bone 42(5):861-70. [Full text article]
 
100. Sheyn D, Pelled G, Zilberman Y, Talasazan F, Frank JM, Gazit D, Gazit Z. (2008) Nonvirally Engineered Porcine Adipose Tissue-Derived Stem Cells: Use in Posterior Spinal Fusion. Stem Cells 26(4):1056-64. [Full text article]

99. Sheyn D, Kimelman-Bleich N, Pelled G, Zilberman Y, Gazit D, Gazit Z. (2008) Ultrasound-based nonviral gene delivery induces bone formation in vivo. Gene Ther 15(4):257-66. [Full text article]
 
98. Zilberman Y, Kallai I, Gafni Y, Pelled G, Kossodo S, Yared W, Gazit D. (2008) Fluorescence molecular tomography enables in vivo visualization and quantification of nonunion fracture repair induced by genetically engineered mesenchymal stem cells. J Orthop Res 26(4):522-30. [Full text article]
 
97. Aslan H, Kimelman-Bleich N, Pelled G, Gazit D. (2008) Molecular targets for tendon neoformation. J Clin Invest 118(2):439-44. [Full text article]
 
96. Gazit Z, Aslan H, Gafni Y, Kimelman N, Pelled G, Gazit D.  (2007) Mesenchymal Stem Cells. In: Atala A, Lanza R, Thomson JA, and Nerem RM (eds.) Principles of Regenerative Medicine. Elsevier Inc. 
 
95. Sheyn D, Pelled G, Gazit D. (2007) Nanotechnologies in Adult Stem Cell Research. In: Vo-Dinh T (ed.) Nanotechnology in Biology and Medicine: Methods, Devices, and Applications. CRC Press LLC. 
 
94. Zvonic S, Ptitsyn AA, Kilroy G, Wu X, Conrad SA, Scott LK, Guilak F, Pelled G, Gazit D, Gimble JM. (2007) Circadian oscillation of gene expression in murine calvarial bone. J Bone Miner Res 22(3):357-65. [Full text article]
 
93. Xie C, Reynolds D, Awad H, Rubery PT, Pelled G, Gazit D, Guldberg RE, Schwarz EM, O'Keefe RJ, Zhang X. (2007) Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering. Tissue Eng 13(3):435-45. [Full text article]
 
92. Risbud MV, Guttapalli A, Tsai TT, Lee JY, Danielson KG, Vaccaro AR, Albert TJ, Gazit Z, Gazit D, Shapiro IM. (2007) Evidence for skeletal progenitor cells in the degenerate human intervertebral disc. Spine 32(23):2537-44. [Full text article]
 
91. Pelled G, Tai K, Sheyn D, Zilberman Y, Kumbar S, Nair LS, Laurencin CT, Gazit D, Ortiz C. (2007) Structural and nanoindentation studies of stem cell-based tissue-engineered bone. J Biomech 40(2):399-411. [Full text article]
 
90. Kimelman N, Pelled G, Helm GA, Huard J, Schwarz EM, Gazit D. (2007) Review: gene- and stem cell-based therapeutics for bone regeneration and repair. Tissue Eng 13(6):1135-50. [Full text article]
 
89. Snedeker JG, Pelled G, Zilberman Y, Gerhard F, Muller R, Gazit D. (2006) Endoscopic cellular microscopy for in vivo biomechanical assessment of tendon function. J Biomed Opt 11(6):064010. [Full text article]
 
88. Kimelman N, Pelled G, Gazit Z, Gazit D. (2006) Applications of gene therapy and adult stem cells in bone bioengineering. Regen Med 1(4):549-61.[Full text article]
 
87. Hoffmann A, Pelled G, Turgeman G, Eberle P, Zilberman Y, Shinar H, Keinan-Adamsky K, Winkel A, Shahab S, Navon G, Gross G, Gazit D. (2006) Neotendon formation induced by manipulation of the Smad8 signalling pathway in mesenchymal stem cells. J Clin Invest 116(4):940-52. [Full text article]
 
86. Gafni Y, Zilberman Y, Ophir Z, Abramovitch R, Jaffe M, Gazit Z, Domb A, Gazit D. (2006) Design of a filamentous polymeric scaffold for in vivo guided angiogenesis. Tissue Eng 12(11):3021-34. [Full text article]
 
85. Aslan H, Zilberman Y, Kandel L, Liebergall M, Oskouian RJ, Gazit D, Gazit Z. (2006) Osteogenic differentiation of noncultured immunoisolated bone marrow-derived CD105+ cells. Stem Cells 24(7):1728-37. [Full text article]
 
84. Aslan H, Zilberman Y, Arbeli V, Sheyn D, Matan Y, Liebergall M, Li JZ, Helm GA, Gazit D, Gazit Z. (2006) Nucleofection-based ex vivo nonviral gene delivery to human stem cells as a platform for tissue regeneration. Tissue Eng 12(4):877-89. [Full text article]
 
83. Aslan H, Ravid-Amir O, Clancy BM, Rezvankhah S, Pittman D, Pelled G, Turgeman G, Zilberman Y, Gazit Z, Hoffmann A, Gross G, Domany E, Gazit D. (2006) Advanced molecular profiling in vivo detects novel function of dickkopf-3 in the regulation of bone formation. J Bone Miner Res 21(12):1935-45. [Full text article]
 
82. Hasharoni A, Zilberman Y, Turgeman G, Helm GA, Liebergall M, Gazit D. (2005) Murine spinal fusion induced by engineered mesenchymal stem cells that conditionally express bone morphogenetic protein-2. J Neurosurg Spine 3(1):47-52. 
 
81. Eliyahu H, Makovitzki A, Azzam T, Zlotkin A, Joseph A, Gazit D, Barenholz Y, Domb AJ. (2005) Novel dextran-spermine conjugates as transfecting agents: comparing water-soluble and micellar polymers. Gene Ther 12(6):494-503. [Full text article]
 
 

  1. Osteogenic Growth Polypeptides Identified From Regenerating Bone Marrow.

  2. Synthetic Peptides And Pseudopeptides Having Osteogenic Activity And Pharmaceutical Compositions Containing The Same.

  3. Genetically Engineered Cells Which Express Bone Morphogenetic Proteins.

  4. Recombinant Human Cell For Bone And Cartilage Cell Formation.

  5. Methods Of Inducing Or Enhancing Connective Tissue Repair.

  6. Composite Scaffolds And Methods Using Same For Generating Complex Tissue Grafts.

  7. Vascular Tissue Engineering.

  8. Methods Of Implanting Mesenchymal Stem Cells For Connective Tissue Formation Or Repair.

  9. Nonvirally Transfected Human Adult Mesenchymal Stem Cells For Skeletal Gene Therapy And Tissue Engineering.

  10. Tak1-Mediated Inhibition Of Osteogenesis.
 

Dr. Zulma Gazit Dr.Gadi Pelled yoram Hadi Aslan dima Nadav kimelman Ayelet ilan

Olga

Shimon
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