Skeletal Biotech Lab Home Page

Hebrew University

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Prof. Gazit Dan, PhD; DMD
(Head, Skeletal Biotech Lab)

Prof. Dan Gazit

Subjects of interest

  • Skeletal gene therapy & tissue engineering.
  • Stem cell isolation and characterization.
  • Novel gene discovery.
  • Nano technology in regenerative medicine.

(Last five years)

141. Liu Q, Tawackoli W, Pelled G, Fan Z, Jin N, Natsuaki Y, Bi X, Gart A, Bae H, Gazit D, Li D. (2014) Detection of low back pain using pH level-dependent imaging of the intervertebral disc using the ratio of R1ρ dispersion and -OH chemical exchange saturation transfer (RROC). Magn Reson Med. 2014 Apr 2. [Epub ahead of print]

140. Antebi B, Pelled G, Gazit D. (2014) Stem Cell Therapy for Osteoporosis. Current Osteoporosis Reports [Full text article]

139. Sheyn D, Cohn Yakubovich D, Kallai I, Su S, Da X, Pelled G, Tawackoli W, Cook-Weins G, Schwarz EM, Gazit D, Gazit Z. (2013) PTH Promotes Allograft Integration in a Calvarial Bone Defect. Mol Pharm, 10(12):4462-71. [Full text article]

138. Bleich-Kimelman N, Kallai I, Sheyn D, Tawackoli W, Gazit Z, Pelled G, Gazit D. (2013) Real-time bioluminescence functional imaging for monitoring tissue formation and regeneration. Methods Mol Biol, 1048:181-93. [Full text article]

137. Liu Q, Jin N, Fan Z, Natsuaki Y, Tawackoli W, Pelled G, Bae H, Gazit D, Li D. (2013) Reliable chemical exchange saturation transfer imaging of human lumbar intervertebral discs using reduced-field-of-view turbo spin echo at 3.0 T. NMR Biomed, 26(12):1672-9. [Full text article]

136. Sheyn D, Pelled G, Tawackoli W, Su S, Ben-David S, Gazit D, Gazit Z. (2013) Transient overexpression of Pparγ2 and C/ebpα in mesenchymal stem cells induces brown adipose tissue formation. Regen Med 8(3):295-308. [Full text article]

135. Mizrahi O, Sheyn D, Tawackoli W, Ben-David S, Su S, Li N, Oh A, Bae H, Gazit D, Gazit Z. (2013), Nucleus pulposus degeneration alters properties of resident progenitor cells. The Spine Journal 13(7):803-14, [Full text article]

134. Benjamin S, Sheyn D, Ben-David S, Oh A, Kallai I, Li N, Gazit D, Gazit Z. (2013) Oxygenated Environment Enhance Both Stem Cell Survival and Osteogenic Differentiation. Tissue Eng Part A 19(5-6):748-58.  [Full text article]

132. Mizrahi O, Sheyn D, Tawackoli W, Kallai I, Oh A, Su S, Da X, Zarrini P, Cook-Wiens G, Gazit D, Gazit Z. (2013) BMP-6 is more efficient in bone formation than BMP-2 when overexpressed in mesenchymal stem cells. Gene Therapy 20(4):370-7.  [Full text article]

133. Ben Arav A, Pelled G, Zilberman Y, Kimelman-Bleich N, Gazit Z, Schwarz EM, Gazit D. (2012) Adeno-Associated Virus-Coated Allografts: A Novel Approach for Cranioplasty. J Tissue Eng Regen Med 6(10):e43-50. [Full text article]

131. Pelled G, Snedeker JG, Ben-Arav A, Rigozzi S, Zilberman Y, Kimelman-Bleich N, Gazit Z, Müller R, Gazit D. (2012) Smad8/BMP2-engineered mesenchymal stem cells induce accelerated recovery of the biomechanical properties of the achilles tendon. J Orthop Res 30(12):1932-9.  [Full text article]

130. Kimelman-Bleich N, Kallai I, Lieberman JR, Schwarz EM, Pelled G, Gazit D. (2012) Gene therapy approaches to regenerating bone. Adv Drug Deliv Rev 64(12):1320:30. [Full text article]

129. Connors MJ, Ehrlich H, Hog M, Godeffroy C, Araya S, Kallai I, Gazit D, Boyce M, Ortiz C. (2012) Three-dimensional structure of the shell plate assembly of the chiton Tonicella marmorea and its biomechanical consequences.Journal of Structural Biology 177(2):314-28. [Full text article]

128. Sheyn D, Kallai I, Tawackoli W, Cohn Yakubovich D, Oh A, Su S, Da X, Lavi A, Kimelman-Bleich N, Zilberman Y, Li N, Bae H, Gazit Z, Pelled G, Gazit D (2011) Gene-modified adult stem cells regenerate vertebral bone defect in a rat model. Mol Pharm 8(5):1592-601. [Full text article]

127. Kallai I, Mizrahi O, Tawackoli W, Gazit Z, Pelled G, Gazit D (2011) Micro–Computed Tomography–Based Structural Analysis of Various Bone-Tissue Regeneration Models. Nature Protocols, 6(1):105-10. [Full text article]

126. Zhang Y, Gazit Z, Pelled G, Gazit D, Vunjak-Novakovic G (2011) Patterning osteogenesis by inducible gene expression in microfluidic culture systems. Integrative Biology 3(1):39-47. [Full text article]

125. Kimelman-Bleich N, Pelled G, Zilberman Y, Kallai I, Mizrahi O, Tawackoli W, Gazit Z, Gazit D (2011) Targeted Gene-and-host Progenitor Cell Therapy for Nonunion Bone Fracture Repair. Molecular Therapy 19(1):53-9. [Full text article]

124. Sheyn D, Pelled G, Netanely D, Domany E, Gazit D (2010) The Effect of Simulated Microgravity on Human Mesenchymal Stem Cells Cultured in an Osteogenic Differentiation System: A Bioinformatics Study. Tissue Eng Part A, 16(11): 3403-3412. [Full text article]

123. Kimelman-Bleich N, Seliktar D, Kallai I, Helm GA, Gazit Z, Gazit D, Pelled G (2011) The effect of ex vivo dynamic loading on the osteogenic differentiation of genetically engineered mesenchymal stem cell model. J Tissue Eng Regen Med 5(5):384-93.
[Full text article]

122. Sheyn D, Rüthemann M, Mizrahi O, Kallai I, Zilberman Y, Tawackoli W, Kanim LE, Zhao L, Bae H, Pelled G, Snedeker J, Gazit D (2010) Genetically Modified Mesenchymal Stem Cells Induce Mechanically Stable Posterior Spine Fusion. Tissue Eng Part A, 16(12):3679-86. [Full text article]

121. Smith BJ, Sutton GM, Wu X, Yu G, Goh BC, Hebert T, Pelled G, Gazit Z, Gazit D, Butler AA, Gimble JM (2011) Ovariectomy and genes encoding core circadian regulatory proteins in murine bone. Osteoporosis International 22(5):1633-9. [Full text article]

120. Kallai I, van Lenthe GH, Ruffoni D, Zilberman Y, Müller R, Pelled G, Gazit D (2010) Quantitative, structural, and image-based mechanical analysis of nonunion fracture repaired by genetically engineered mesenchymal stem cells. J Biomech 43(12):2315-20. [Full text article]

119. Garty S, Kimelman-Bleich N, Hayouka Z, Cohn D, Friedler A, Pelled G, Gazit D (2010) Peptide-Modified "Smart" Hydrogels and Genetically Engineered Stem Cells for Skeletal Tissue Engineering. Biomacromolecules 11(6):1516-1526. [Full text article]

118. Song J, Reichert S, Kallai I, Gazit D, Wund M, Boyce MC, Ortiz C. (2010) Quantitative microstructural studies of the armor of the marine threespine stickleback (Gasterosteus aculeatus). J Struct Biol 171(3):318-31. [Full text article]

117. Sheyn D, Mizrahi O, Benjamin S, Pelled G, Gazit D. (2010) Genetically modified cells in regenerative medicine and tissue engineering. Advanced Drug Delivery Reviews 62(7-8):683-698. [Full text article]

116. Saar G, Zilberman Y, Shinar H, Keinan-Adamsky K, Pelled G, Gazit D, Navon G. (2010) Monitoring of the Effect of Intervertebral Disc Nucleus Pulposus Ablation by MRI. NMR in Biomedicine 23(6):554-62. [Full text article]

115. Pelled G, Ben Arav A, Hock C, Reynolds DG, Yazici C, Zilberman Y, Gazit Z, Awad H, Gazit D, Schwarz E. (2009) Direct Gene Therapy for Bone Regeneration: Gene Delivery, Animal Models and Outcome Measures. Tissue Eng Part B 16(1):13-20. [Full text article]

114. Kimelman-Bleich N, Pelled G, Sheyn D, Kallai I, Zilberman Y, Mizrahi O, Tal Y, Tawackoli W, Gazit Z, Gazit D. (2009) The use of a synthetic oxygen carrier-enriched hydrogel to enhance mesenchymal stem cell-based bone formation in vivo. Biomaterials 30(27):4639-48. [Full text article]

113.  Stok KS, Pelled G, Zilberman Y, Kallai I, Goldhahn J, Gazit D, Muller R. (2009) Revealing the interplay of bone and cartilage in osteoarthritis through multimodel imaging of murine joints. Bone 45(3):414-22. [Full text article]

112. Gazit D. (2009) Stem Cell Research: Regenerating the Skeleton and Craniofacial Complex. Alpha Omegan 102(1):31-4. [Full text article]

111. Snedeker JG, Ben-Arav A, Zilberman Y, Pelled G, Gazit D. (2009) Functional Fibered Confocal Microscopy: a Promising Tool for Assessing Tendon Regeneration. Tissue Eng Part C 15(3):485:491. [Full text article].

110. Dinser R, Pelled G, Muller-Ladner U, Gazit D, Neumann E. (2009) Expression of Brachyury in mesenchymal progenitor cells leads to cartilage-like tissue that is resistant to the destructive effect of rheumatoid arthritis synovial fibroblasts. J Tissue Eng Regen Med 3(2):124-8. [Full text article]

109. Czerninski R, Krichevsky S, Ashab Y, Gazit D, Patel V, Ben-Yehuda D. (2009) Promoter hypermethylation of mismatch repair genes, hMLH1 and hMSH2 in oral squamous cell carcinoma. Oral Diseases 15(3):206-13. [Full text article]

108. Snedeker JG, Pelled G, Zilberman Y, Ben Arav A, Huber E, Muller R, Gazit D. (2009) An Analytical Model for Elucidating Tendon Tissue Structure and Biomechanical Function from in vivo Cellular Confocal Microscopy Images. Cells Tissues Organs 190(2):111-119. [Full text article]

107. Aslan H, Sheyn D, Gazit D. (2009) Genetically engineered mesenchymal stem cells: application in spine therapy. Regen Med 4(1):99-108. [Full text article]

106. Gafni Y, Ptitsyn AA, Pelled G, Zilberman Y, Gimble JM, Gazit D. (2009) Circadian Rhythm of Osteocalcin in the Maxillomandibular Complex. J Dent Res 88(1):45-50. [Full text article]

105. Ziv R, Steinhardt Y, Pelled G, Gazit D, Rubinsky B. (2009) Micro-electroporation of mesenchymal stem cells with alternating electrical current pulses. Biomed Microdevices 11(1):95-101. [Full text article]


  1. Osteogenic Growth Polypeptides Identified From Regenerating Bone Marrow.

  2. Synthetic Peptides And Pseudopeptides Having Osteogenic Activity And Pharmaceutical Compositions Containing The Same.

  3. Genetically Engineered Cells Which Express Bone Morphogenetic Proteins.

  4. Recombinant Human Cell For Bone And Cartilage Cell Formation.

  5. Methods Of Inducing Or Enhancing Connective Tissue Repair.

  6. Composite Scaffolds And Methods Using Same For Generating Complex Tissue Grafts.

  7. Vascular Tissue Engineering.

  8. Methods Of Implanting Mesenchymal Stem Cells For Connective Tissue Formation Or Repair.

  9. Nonvirally Transfected Human Adult Mesenchymal Stem Cells For Skeletal Gene Therapy And Tissue Engineering.

  10. Tak1-Mediated Inhibition Of Osteogenesis.

Prof. Dan Gazit Dr. Zulma Gazit Dr.Gadi Pelled Ilan Kallai Dr. Ben Antebi
Doron Galina
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