Molecular targets for tendon neoformation

Citation:

Aslan H, Kimelman-Bleich N, Pelled G, Gazit D. Molecular targets for tendon neoformation [Internet]. J Clin Invest 2008;118(2):439-44. Copy at http://www.tinyurl.com/y4dapqo3

Abstract:

Tendons and ligaments are unique forms of connective tissue that are considered an integral part of the musculoskeletal system. The ultimate function of tendon is to connect muscles to bones and to conduct the forces generated by muscle contraction into movements of the joints, whereas ligaments connect bone to bone and provide joint stabilization. Unfortunately, the almost acellular and collagen I-rich structure of tendons and ligaments makes them very poorly regenerating tissues. Injured tendons and ligaments are considered a major clinical challenge in orthopedic and sports medicine. This Review discusses the several factors that might serve as molecular targets that upon activation can enhance or lead to tendon neoformation.

Notes:

Aslan, Hadi Kimelman-Bleich, Nadav Pelled, Gadi Gazit, Dan eng Review 2008/02/05 09:00 J Clin Invest. 2008 Feb;118(2):439-44. doi: 10.1172/JCI33944.

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