Quantitative chemical exchange saturation transfer MRI of intervertebral disc in a porcine model

Citation:

Zhou Z, Bez M, Tawackoli W, Giaconi J, Sheyn D, de Mel S, Maya MM, Pressman BD, Gazit Z, Pelled G, Gazit D, Li D. Quantitative chemical exchange saturation transfer MRI of intervertebral disc in a porcine model [Internet]. Magn Reson Med 2016;76(6):1677-1683. Copy at http://www.tinyurl.com/ya5zwx24

Abstract:

{PURPOSE: Previous studies have associated low pH in intervertebral discs (IVDs) with discogenic back pain. The purpose of this study was to determine whether quantitative CEST (qCEST) MRI can be used to detect pH changes in IVDs in vivo. METHODS: The exchange rate ksw between glycosaminoglycan (GAG) protons and water protons was determined from qCEST analysis. Its dependence on pH value was investigated in GAG phantoms with varying pH and concentrations. The relationship between ksw and pH was studied further in vivo in a porcine model on a 3T MR scanner and validated using a pH meter. Sodium lactate was injected into the IVDs to induce various pH values within the discs ranging from 5 to 7. RESULTS: Phantom and animal results revealed that ksw measured using qCEST MRI is highly correlated with pH level. In the animal studies, the relationship can be described as ksw =9.2 x 106 x 10-pH + 196.9

Notes:

1522-2594 Zhou, Zhengwei Bez, Maxim Tawackoli, Wafa Giaconi, Joseph Sheyn, Dmitriy de Mel, Sandra Maya, Marcel M Pressman, Barry D Gazit, Zulma Pelled, Gadi Gazit, Dan Li, Debiao R01 AR066517/AR/NIAMS NIH HHS/United States Journal Article United States Magn Reson Med. 2016 Dec;76(6):1677-1683. doi: 10.1002/mrm.26457. Epub 2016 Sep 26.

Publisher's Version

Last updated on 10/29/2017