Skeletal Biotech Lab Home Page

Hebrew University

Last Updated:
15-Jan-2012


Yoram Zilberman, PhD; DMD
(Scientist)

Dr. Yoram Zilberman
Email: yoram.zilberman@huji.ac.il

Subjects of Interest

  • Tissue engineering and gene therapy to bone, cartilage and ligament.
  • Microsurgery and animal models for skeletal defects and disorders.
  • Imaging technologies including:
    • Bioluminescence analysis for molecular tracking of delivered genes.
    • Faxitron for the fine and precise analysis of bone and cartilage structure and remodeling.
    • MRI and micro-MRI analysis for bone, cartilage and ligament.
    • Micro-MRI analysis IN VIVO AND IN VITRO of INTERVERTEBRAL DISC, tendon and ligament repair.
    • In vivo fibered confocal fluorescent microscopy.
    • Micro-CT analysis of bone tissue.
  • Animals models and microsurgery.

Publications list: (recent five years)

Sheyn D, Kallai I, Tawackoli W, Cohn Yakubovich D, Oh A, Su S, Da X, Lavi A, Kimelman-Bleich N, Zilberman Y, Li N, Bae H, Gazit Z, Pelled G, Gazit D.
Gene-modified adult stem cells regenerate vertebral bone defect in a rat model.
Mol Pharm, 8(5):1592-601. (2011) 
[Full text article]

Kimelman-Bleich N, Pelled G, Zilberman Y, Kallai I, Mizrahi O, Tawackoli W, Gazit Z, Gazit D.
Targeted Gene-and-host Progenitor Cell Therapy for Nonunion Bone Fracture Repair.

Molecular Therapy, 
19(1):53-9. (2011) [Full text article]

Sheyn D, Rüthemann M, Mizrahi O, Kallai I, Zilberman Y, Tawackoli W, Kanim LE, Zhao L, Bae H, Pelled G, Snedeker J, Gazit D.
Genetically Modified Mesenchymal Stem Cells Induce Mechanically Stable Posterior Spine Fusion.
Tissue Eng Part A
, 16(12):3679-86. (2010) [Full text article]

Kallai I, van Lenthe GH, Ruffoni D, Zilberman Y, Müller R, Pelled G, Gazit D.
Quantitative, structural, and image-based mechanical analysis of nonunion fracture repaired by genetically engineered mesenchymal stem cells.

J Biomech 43(12):2315-20. (2010)
[Full text article]

Saar G, Zilberman Y, Shinar H, Keinan-Adamsky K, Pelled G, Gazit D, Navon G.
Monitoring of the Effect of Intervertebral Disc Nucleus Pulposus Ablation by MRI.
NMR in Biomedicine 23(6):554-62. (2010)
[Full text article]


Pelled G, Ben Arav A, Hock C, Reynolds DG, Yazici C, Zilberman Y, Gazit Z, Awad H, Gazit D, Schwarz E.

Direct Gene Therapy for Bone Regeneration: Gene Delivery, Animal Models and Outcome Measures.
Tissue Eng Part B 16(1):13-20. (2010) [Full text article]

Kimelman-Bleich N, Pelled G, Sheyn D, Kallai I, Zilberman Y, Mizrahi O, Tal Y, Tawackoli W, Gazit Z, Gazit D.
The use of a synthetic oxygen carrier-enriched hydrogel to enhance mesenchymal stem cell-based bone formation in vivo.
Biomaterials 30(27):4639-48. (2009) [Full text article]

Stok KS, Pelled G, Zilberman Y, Kallai I, Goldhahn J, Gazit D, Muller R.
Revealing the interplay of bone and cartilage in osteoarthritis through multimodel imaging of murine joints.
Bone 45(3):414-22. (2009)
[Full text article]


Snedeker JG, Ben-Arav A, Zilberman Y, Pelled G, Gazit D.
Functional Fibered Confocal Microscopy: a Promising Tool for Assessing Tendon Regeneration.
Tissue Eng Part C 15(3):485:491. (2009) [Full text article]


Snedeker JG, Pelled G, Zilberman Y, Ben Arav A, Huber E, Muller R, Gazit D.
An Analytical Model for Elucidating Tendon Tissue Structure and Biomechanical Function from in vivo Cellular Confocal Microscopy Images.
Cells Tissues Organs 190(2):111-119. (2009) [Full text article]


Gafni Y, Ptitsyn AA, Pelled G, Zilberman Y, Gimble JM, Gazit D.
Circadian Rhythm of Osteocalcin in the Maxillomandibular Complex.
J Dent Res 88(1):45-50. (2009) [Full text article]

Steinhardt Y, Aslan H, Regev E, Zilberman Y, Kallai I, Gazit D, Gazit Z.
Maxillofacial-Derived Stem Cells Regenerate Critical Mandibular Bone Defect.

Tissue Eng Part A 14(11):1763-73. (2008) [Full text article]
 
Tai K, Pelled G, Sheyn D, Bershteyn A, Han L, Kallai I, Zilberman Y, Ortiz C, Gazit D.
Nanobiomechanics of Repair Bone Regenerated by Genetically Modified Mesenchymal Stem Cells.
Tissue Eng Part A 14(10):1709-20. (2008)
[Full text article]

Zilberman Y, Gafni Y, Pelled G, Gazit Z, Gazit D.
Bioluminescent imaging in bone.
Methods Mol Biol 455:261-72. (2008) [Full text article]

Sheyn D, Pelled G, Zilberman Y, Talasazan F, Frank JM, Gazit D, Gazit Z.
Nonvirally Engineered Porcine Adipose Tissue-Derived Stem Cells: Use in Posterior Spinal Fusion.
Stem Cells 26(4):1056-64. (2008) [Full text article]

Sheyn D, Kimelman-Bleich N, Pelled G, Zilberman Y, Gazit D, Gazit Z.
Ultrasound-based nonviral gene delivery induces bone formation in vivo.
Gene Ther 15(4):257-66. (2008) [Full text article]

Zilberman Y, Kallai I, Gafni Y, Pelled G, Kossodo S, Yared W, Gazit D.
Fluorescence molecular tomography enables in vivo visualization and quantification of nonunion fracture repair induced by genetically engineered mesenchymal stem cell.
J Orthop Res 26(4):522-30. (2008)
[Full text article]


Pelled G, Tai K, Sheyn D, Zilberman Y, Kumbar S, Nair LS, Laurencin CT, Gazit D, Ortiz C.
Structural and nanoindentation studies of stem cell-based tissue-engineered bone.
J Biomech 40(2):399-411. (2007)
[Full text article]
 
 


Prof. Dan Gazit Dr. Zulma Gazit Dr.Gadi Pelled yoram Nadav kimelman Ilan Kallai

Olga

Shimon

Amir Yosi Navaro Lior Ben-Assaf
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