@article {17108,
	title = {Genetically modified cells in regenerative medicine and tissue engineering},
	journal = {Adv Drug Deliv Rev},
	volume = {62},
	number = {7-8},
	year = {2010},
	note = {Sheyn, Dima Mizrahi, Olga Benjamin, Shimon Gazit, Zulma Pelled, Gadi Gazit, Dan eng R01 AR056694/AR/NIAMS NIH HHS/ R03 AR057143/AR/NIAMS NIH HHS/ R43 AR057587/AR/NIAMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov{\textquoteright}t Research Support, U.S. Gov{\textquoteright}t, Non-P.H.S. Review Netherlands 2010/02/02 06:00 Adv Drug Deliv Rev. 2010 Jun 15;62(7-8):683-98. doi: 10.1016/j.addr.2010.01.002. Epub 2010 Jan 28.},
	pages = {683-98},
	type = {Journal Article},
	abstract = {Regenerative medicine appears to take as its patron, the Titan Prometheus, whose liver was able to regenerate daily, as the field attempts to restore lost, damaged, or aging cells and tissues. The tremendous technological progress achieved during the last decade in gene transfer methods and imaging techniques, as well as recent increases in our knowledge of cell biology, have opened new horizons in the field of regenerative medicine. Genetically engineered cells are a tool for tissue engineering and regenerative medicine, albeit a tool whose development is fraught with difficulties. Gene-and-cell therapy offers solutions to severe problems faced by modern medicine, but several impediments obstruct the path of such treatments as they move from the laboratory toward the clinical setting. In this review we provide an overview of recent advances in the gene-and-cell therapy approach and discuss the main hurdles and bottlenecks of this approach on its path to clinical trials and prospective clinical practice.},
	keywords = {Animals Cell Transplantation/methods Clinical Trials as Topic Genetic Engineering/*methods Genetic Therapy/methods Humans Regenerative Medicine/*methods Stem Cell Transplantation/methods Tissue Engineering/*methods},
	issn = {1872-8294 (Electronic) 0169-409X (Linking)},
	doi = {10.1016/j.addr.2010.01.002},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/20114067},
	author = {Sheyn, D. and Mizrahi, O. and Benjamin, S. and Gazit, Z. and Pelled, G. and Gazit, D.}
}
