Acromegaly and proximal femoral fracture in an aged person: bone histomorphometry, vitamin D metabolites and parathormone

Citation:

Lowenthal MN, Galinsky D, Fried V, Castel H, Shany S, Gazit D. Acromegaly and proximal femoral fracture in an aged person: bone histomorphometry, vitamin D metabolites and parathormone [Internet]. Isr J Med Sci 1990;26(5):280-3. Copy at http://www.tinyurl.com/y62de2hj

Abstract:

Osteoporosis and fractures are rare in acromegaly. An 84-year-old acromegalic woman sustained a fractured neck of femur in a fall. Histomorphometric analysis of an iliac crest biopsy showed marked osteoporosis and augmented resorption parameters. Cortical plates were very thin and bone volume was 8.5%; 12.5% is the reference value for women at this age. The total resorption surfaces were 23.7% compared with the reference value of 8%. We conjecture that postmenopausal and involutional osteoporosis were far advanced before the development of acromegaly, explaining the coexistence of the two conditions. Parathormone (65 pmol/l) and 24,25-dihydroxyvitamin D (1.34 ng/ml) levels were within normal limits, but those of 25-hydroxyvitamin D (5.6 ng/ml) and 1,25-dihydroxyvitamin D (15 pg/ml) were markedly decreased.

Notes:

Lowenthal, M N Galinsky, D Fried, V Castel, H Shany, S Gazit, D eng Case Reports Israel 1990/05/01 Isr J Med Sci. 1990 May;26(5):280-3.

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